Folate (As Metafolin) 1000µg 60 Tablets vs Vegan Methyl Folate, 400 mcg, 60 Veggie Capsules

Q: Which is better, Folate (As Metafolin) 1000µg 60 Tablets or Vegan Methyl Folate, 400 mcg, 60 Veggie Capsules?

Folate (As Metafolin) 1000µg 60 Tablets scores 86.0/100 while Vegan Methyl Folate, 400 mcg, 60 Veggie Capsules scores 81.0/100 in our analysis. Folate (As Metafolin) 1000µg 60 Tablets is the higher-rated product overall.

Q: Is Folate (As Metafolin) 1000µg 60 Tablets worth the price compared to Vegan Methyl Folate, 400 mcg, 60 Veggie Capsules?

Folate (As Metafolin) 1000µg 60 Tablets scores 73.0/100 for value, while Vegan Methyl Folate, 400 mcg, 60 Veggie Capsules scores 80.0/100. Check our price comparison above for the latest UK prices.

Side-by-side comparison of scores, ingredients, prices and real customer feedback for Folate (As Metafolin) 1000µg 60 Tablets and Vegan Methyl Folate, 400 mcg, 60 Veggie Capsules.

Last verified: 07 Apr 2026 · Based on 107 reviews

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86.0

Quick Answer

Folate (As Metafolin) 1000µg 60 Tablets scores 86.0/100 vs Vegan Methyl Folate, 400 mcg, 60 Veggie Capsules at 81.0/100. Folate (As Metafolin) 1000µg 60 Tablets wins on effectiveness, ingredient quality, side effects. Vegan Methyl Folate, 400 mcg, 60 Veggie Capsules is stronger on value for money.

Which is better: Folate (As Metafolin) 1000µ... or Vegan Methyl Folate, 400 mc...?

Jarrow Formulas wins on value — nearly half the price (£9.70 vs £16.94) with near-identical effectiveness scores and a cleaner, allergen-free formula. Choose Solgar if you require the higher 1000mcg therapeutic dose, particularly with a confirmed MTHFR mutation and medical guidance.

— AIScored Editorial Team

How Do the Scores Compare?

Folate (As Metafolin) 1000µ...

Vegan Methyl Folate, 400 mc...

	Folate (As Metafolin) 1000µ... Solgar	Vegan Methyl Folate, 400 mc... Jarrow Formulas
Overall Score	86.0	81.0
Effectiveness	88.0/100 Best	85.0/100
Ingredient Quality	93.0/100 Best	90.0/100
Value for Money	73.0/100	80.0/100 Best
Side Effects	93.0/100 Best	77.0/100
Certifications	70.0/100 Best	35.0/100
Best Price	£16.94 Amazon UK →	£9.70 iHerb → Cheapest
Form	Tablets	None
Dose	None	None
Third-Party Tested	✗ No	✗ No
Reviews Analysed	57	50

Folate (As Metafolin) 1000µg 60 Tablets

Pros

✓Bioactive Metafolin® form (L-methylfolate) absorbed directly without MTHFR conversion — critical for MTHFR gene variant carriers
✓Multiple reviewers confirmed improved blood folate levels via lab tests, not just subjective feeling
✓Widely reported energy improvement and reduction in fatigue after consistent use
✓Clean ingredient profile — certified gluten-free, Kosher Parve, no artificial additives; packaged in glass bottle

Cons

✗Not third-party tested (e.g. NSF, Informed Sport) — relevant for those needing full verification
✗1000mcg dose significantly exceeds the standard adult RDA (400mcg) and pregnancy recommendation (600mcg) — medical supervision advisable
✗Premium price point relative to standard folic acid alternatives; 60 tablets is a 2-month supply at 1/day
✗Isolated reports of tablets being difficult to swallow for some users

Best For

Women planning pregnancy or in early pregnancy People with confirmed MTHFR gene mutations (C677T, A1298C) Those with diagnosed folate deficiency or elevated homocysteine Anyone who hasn't responded well to standard folic acid supplementation Individuals on methotrexate or other medications that deplete folate People seeking a clean, additive-free premium folate supplement

Amazon UK £16.94 Holland & Barrett £19.20

View full review →

Vegan Methyl Folate, 400 mcg, 60...

Pros

✓Quatrefolic® (6S)-5-MTHF bypasses MTHFR conversion issues — multiple reviewers specifically chose it for this reason
✓Small capsule size consistently praised; neutral taste, no smell
✓Energy boost and mood improvement reported by reviewers after a few weeks of regular use
✓Clean excipient list — vegetable-source magnesium stearate, HPMC capsule, no unnecessary fillers

Cons

✗Can cause anxiety or agitation in sensitive individuals — one reviewer switched to folinic acid specifically because of this
✗Works best paired with B12 and B6; some reviewers noted irritability when taken without a B-complex
✗Not universally appropriate — one reviewer's doctor advised against the methyl form due to transulfation pathway issues
✗No verified third-party testing per product specs

Best For

People with MTHFR gene variants who cannot efficiently convert synthetic folic acid Women planning pregnancy or in the first trimester needing bioavailable B9 Those with confirmed folate deficiency prescribed methylfolate by a doctor People with thalassemia or related anaemia where iron supplementation is not suitable

iHerb £9.70

View full review →

What does the data say about Folate (As Metafolin) ... vs Vegan Methyl Folate, 4...?

Both products use bioactive methylfolate rather than standard folic acid, meaning neither requires MTHFR enzyme conversion — an important distinction for anyone with C677T or A1298C gene variants. The key difference is dose: Solgar delivers 1,000mcg per tablet, well above the standard 400mcg recommendation, while Jarrow sits at a more conservative 400mcg per capsule. Solgar scores 86/100 at £16.94; Jarrow scores 85/100 at £9.70, with noticeably better value marks (82 versus 73 out of 100).

If you have a confirmed deficiency, elevated homocysteine, or your GP has suggested higher-dose supplementation, Solgar's 1,000mcg makes clinical sense — though medical supervision is sensible at that level. For most people planning pregnancy or supplementing preventatively, Jarrow's 400mcg is the more appropriate starting point, and at nearly half the price it's significantly easier to sustain long-term.

On practicalities, Jarrow has the cleaner profile: small veggie capsules, no gluten, soy, dairy, eggs, or nuts, and consistently praised for easy daily compliance. Solgar's tablets are straightforward but not explicitly allergen-free. Neither product carries third-party certification, so those requiring independent verification will need to look elsewhere regardless of which they choose.

Folate (As Metafolin) 1000µg 60 Tablets Winner 86.0/100

Solgar's Folate as Metafolin 1000mcg delivers L-methylfolate (5-MTHF) via the patented Metafolin® form — the bioidentical, body-ready form of folate that bypasses the MTHFR enzyme conversion required by standard folic acid.

Effectiveness

Folate (As Metaf..

88.0/100

Vegan Methyl Fol..

85.0/100

Ingredient Quality

Folate (As Metaf..

93.0/100

Vegan Methyl Fol..

90.0/100

Value for Money

Folate (As Metaf..

73.0/100

Vegan Methyl Fol..

80.0/100

Side Effects

Folate (As Metaf..

93.0/100

Vegan Methyl Fol..

77.0/100

Certifications

Folate (As Metaf..

70.0/100

Vegan Methyl Fol..

35.0/100

What are the key differences?

Folate (As Metafolin) 1.. is best for: Women planning pregnancy or in early pregnancy, People with confirmed MTHFR gene mutations (C677T, A1298C)

Vegan Methyl Folate, 40.. is best for: People with MTHFR gene variants who cannot efficiently convert synthetic folic acid, Women planning pregnancy or in the first trimester needing bioavailable B9

Frequently Asked Questions

Which is better, Folate (As Metafolin) 1000µg 60 Tablets or Vegan Methyl Folate, 400 mcg, 60 Veggie Capsules? ▼

Folate (As Metafolin) 1000µg 60 Tablets scores 86.0/100 overall while Vegan Methyl Folate, 400 mcg, 60 Veggie Capsules scores 81.0/100. Folate (As Metafolin) 1000µg 60 Tablets comes out ahead, scoring higher on effectiveness (88.0 vs 85.0). Folate (As Metafolin) 1000µg 6 is best suited for Women planning pregnancy or in early pregnancy and People with confirmed MTHFR gene mutations (C677T, A1298C). Vegan Methyl Folate, 400 mcg, is better for People with MTHFR gene variants who cannot efficiently convert synthetic folic acid and Women planning pregnancy or in the first trimester needing bioavailable B9.

Is Folate (As Metafolin) 1000µg 60 Tablets worth the price compared to Vegan Methyl Folate, 400 mcg, 60 Veggie Capsules? ▼

Folate (As Metafolin) 1000µg 60 Tablets costs £16.94 while Vegan Methyl Folate, 400 mcg, 60 Veggie Capsules is £9.70. For value, Folate (As Metafolin) 1000µg 60 Tablets scores 73.0/100 vs Vegan Methyl Folate, 400 mcg, 60 Veggie Capsules's 80.0/100. Vegan Methyl Folate, 400 mcg, 60 Veggie Capsules delivers better value relative to its quality.

Which has fewer side effects? ▼

Folate (As Metafolin) 1000µg 60 Tablets scores 93.0/100 for side effects (higher means fewer reported issues) while Vegan Methyl Folate, 400 mcg, 60 Veggie Capsules scores 77.0/100. Reviewers report fewer side effects with Folate (As Metafolin) 1000µg 60 Tablets. For certification and testing, Folate (As Metafolin scores 70.0/100 vs Vegan Methyl Folate,'s 35.0/100. Always consult a healthcare professional before starting any supplement.