Folate (As Metafolin) 1000µg 60 Tablets vs Folate (As Metafolin®) 400µg 50 Tablets

Q: Which is better, Folate (As Metafolin) 1000µg 60 Tablets or Folate (As Metafolin®) 400µg 50 Tablets?

Folate (As Metafolin) 1000µg 60 Tablets scores 86.0/100 while Folate (As Metafolin®) 400µg 50 Tablets scores 86.0/100 in our analysis. Both products are equally rated.

Q: Is Folate (As Metafolin) 1000µg 60 Tablets worth the price compared to Folate (As Metafolin®) 400µg 50 Tablets?

Folate (As Metafolin) 1000µg 60 Tablets scores 73.0/100 for value, while Folate (As Metafolin®) 400µg 50 Tablets scores 68.0/100. Check our price comparison above for the latest UK prices.

Side-by-side comparison of scores, ingredients, prices and real customer feedback for Folate (As Metafolin) 1000µg 60 Tablets and Folate (As Metafolin®) 400µg 50 Tablets.

Last verified: 04 Apr 2026 · Based on 115 reviews

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86.0

Quick Answer

Folate (As Metafolin) 1000µg 60 Tablets scores 86.0/100 vs Folate (As Metafolin®) 400µg 50 Tablets at 86.0/100. Folate (As Metafolin) 1000µg 60 Tablets wins on value for money. Folate (As Metafolin®) 400µg 50 Tablets is stronger on side effects and certifications.

Which is better: Folate (As Metafolin) 1000µ... or Folate (As Metafolin®) 400µ...?

Solgar's 400µg version (£9.20) wins for standard use—same 86/100 score as the 1000µg, but costs £7.74 less and matches pregnancy guidelines instead of exceeding recommended doses. Pick the 1000µg only if your doctor confirms MTHFR mutation or deficiency requiring higher supplementation.

— AIScored Editorial Team

How Do the Scores Compare?

Folate (As Metafolin) 1000µ...

Folate (As Metafolin®) 400µ...

	Folate (As Metafolin) 1000µ... Solgar	Folate (As Metafolin®) 400µ... Solgar
Overall Score	86.0	86.0
Effectiveness	88.0/100 Best	88.0/100 Best
Ingredient Quality	93.0/100 Best	93.0/100 Best
Value for Money	73.0/100 Best	68.0/100
Side Effects	93.0/100	95.0/100 Best
Certifications	70.0/100	76.0/100 Best
Best Price	£16.94 Amazon UK →	£9.20 Holland & Barrett → Cheapest
Form	Tablets	Tablets
Dose	None	None
Third-Party Tested	✗ No	✗ No
Reviews Analysed	57	58

Folate (As Metafolin) 1000µg 60 Tablets

Pros

✓Bioactive Metafolin® form (L-methylfolate) absorbed directly without MTHFR conversion — critical for MTHFR gene variant carriers
✓Multiple reviewers confirmed improved blood folate levels via lab tests, not just subjective feeling
✓Widely reported energy improvement and reduction in fatigue after consistent use
✓Clean ingredient profile — certified gluten-free, Kosher Parve, no artificial additives; packaged in glass bottle

Cons

✗Not third-party tested (e.g. NSF, Informed Sport) — relevant for those needing full verification
✗1000mcg dose significantly exceeds the standard adult RDA (400mcg) and pregnancy recommendation (600mcg) — medical supervision advisable
✗Premium price point relative to standard folic acid alternatives; 60 tablets is a 2-month supply at 1/day
✗Isolated reports of tablets being difficult to swallow for some users

Best For

Women planning pregnancy or in early pregnancy People with confirmed MTHFR gene mutations (C677T, A1298C) Those with diagnosed folate deficiency or elevated homocysteine Anyone who hasn't responded well to standard folic acid supplementation Individuals on methotrexate or other medications that deplete folate People seeking a clean, additive-free premium folate supplement

Amazon UK £16.94 Holland & Barrett £19.20

View full review →

Folate (As Metafolin®) 400µg 50 Tablets

Pros

✓Uses Metafolin® (L-5-methyltetrahydrofolate), the bioactive form directly usable by the body — superior absorption vs. synthetic folic acid
✓Highly effective for MTHFR mutation carriers who cannot convert regular folic acid
✓Multiple reviewers report confirmed improvements in blood folate levels via lab testing
✓Small, easy-to-swallow tablets with neutral taste and no reported digestive side effects

Cons

✗Small pack size — 50 tablets is only ~7 weeks' supply at the standard one-per-day dose
✗Not third-party tested per product specs, limiting independent purity verification
✗One Amazon reviewer reported receiving 46 tablets instead of 50 (possible quality control lapse)
✗Several iHerb reviews appear to describe the 1000mcg/120-tablet variant rather than this 400µg/50-tablet product, slightly muddying the review signal

Best For

Women planning pregnancy or currently pregnant MTHFR mutation carriers who cannot efficiently convert synthetic folic acid People with diagnosed folate deficiency Those seeking a clean, minimal-additive B-vitamin supplement Anyone wanting a well-trusted, established supplement brand

Holland & Barrett £9.20 Amazon UK £16.94

View full review →

What does the data say about Folate (As Metafolin) ... vs Folate (As Metafolin®)...?

Both Folate 1000µg 60 Tablets and Folate 400µg 50 Tablets from Solgar use the same Metafolin form of L-methylfolate. This bioactive version gets absorbed straight away without any conversion step. The real difference sits in the dose and pack size. One delivers 1000µg per tablet across 60 tablets while the other gives 400µg across 50 tablets. They share identical scores too with both hitting 86.0/100 overall 88.0/100 on effectiveness and 93.0/100 on ingredient quality.

Women planning pregnancy or in early pregnancy who need higher amounts should pick the Folate 1000µg 60 Tablets at £16.94 especially if they carry MTHFR mutations like C677T or A1298C or show elevated homocysteine. It offers better value at 73.0/100 compared with 68.0/100 for the smaller pack. Those sticking to standard pregnancy guidance of 600µg or who want a lower daily amount will find the Folate 400µg 50 Tablets at £9.20 more suitable. Reviewers for both report lab confirmed rises in blood folate levels and less fatigue after regular use.

Practical points stay simple. Both come as standard tablets with no mentioned differences in size taste or allergens. The 50 tablet pack lasts roughly seven weeks at one per day so you will need to buy more often. Pick based on your exact needs and how much you want to spend per month.

Folate (As Metafolin) 1000µg 60 Tablets Winner 86.0/100

Solgar's Folate as Metafolin 1000mcg delivers L-methylfolate (5-MTHF) via the patented Metafolin® form — the bioidentical, body-ready form of folate that bypasses the MTHFR enzyme conversion required by standard folic acid.

Effectiveness

Folate (As Metaf..

88.0/100

Folate (As Metaf..

88.0/100

Ingredient Quality

Folate (As Metaf..

93.0/100

Folate (As Metaf..

93.0/100

Value for Money

Folate (As Metaf..

73.0/100

Folate (As Metaf..

68.0/100

Side Effects

Folate (As Metaf..

93.0/100

Folate (As Metaf..

95.0/100

Certifications

Folate (As Metaf..

70.0/100

Folate (As Metaf..

76.0/100

What are the key differences?

Folate (As Metafolin) 1.. is best for: Women planning pregnancy or in early pregnancy, People with confirmed MTHFR gene mutations (C677T, A1298C)

Folate (As Metafolin®) .. is best for: Women planning pregnancy or currently pregnant, MTHFR mutation carriers who cannot efficiently convert synthetic folic acid

Frequently Asked Questions

Which is better, Folate (As Metafolin) 1000µg 60 Tablets or Folate (As Metafolin®) 400µg 50 Tablets? ▼

Folate (As Metafolin) 1000µg 60 Tablets scores 86.0/100 overall while Folate (As Metafolin®) 400µg 50 Tablets scores 86.0/100. Both score equally overall — the difference comes down to individual dimensions. Folate (As Metafolin) 1000µg 6 is best suited for Women planning pregnancy or in early pregnancy and People with confirmed MTHFR gene mutations (C677T, A1298C). Folate (As Metafolin®) 400µg 5 is better for Women planning pregnancy or currently pregnant and MTHFR mutation carriers who cannot efficiently convert synthetic folic acid.

Is Folate (As Metafolin) 1000µg 60 Tablets worth the price compared to Folate (As Metafolin®) 400µg 50 Tablets? ▼

Folate (As Metafolin) 1000µg 60 Tablets costs £16.94 while Folate (As Metafolin®) 400µg 50 Tablets is £9.20. For value, Folate (As Metafolin) 1000µg 60 Tablets scores 73.0/100 vs Folate (As Metafolin®) 400µg 50 Tablets's 68.0/100. Folate (As Metafolin) 1000µg 60 Tablets delivers better value relative to its quality.

Which has fewer side effects? ▼

Folate (As Metafolin) 1000µg 60 Tablets scores 93.0/100 for side effects (higher means fewer reported issues) while Folate (As Metafolin®) 400µg 50 Tablets scores 95.0/100. Reviewers report fewer side effects with Folate (As Metafolin®) 400µg 50 Tablets. For certification and testing, Folate (As Metafolin scores 70.0/100 vs Folate (As Metafolin's 76.0/100. Always consult a healthcare professional before starting any supplement.